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Results: To understand dysregulated tumor cell-intrinsic signaling, promoter enrichment analysis on differentially expressed genes (DEGs) in -MUT compared to -WT identified notable suppression of an immune-regulatory module of TFs with IRF2 and POU2F1 ranked among the top candidates

Adv Drug Deliv Rev 191:114583 130

Links The Glutathione Oxidation Reduction (Redox) Cycle

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Tamoxifen and trametinib have been shown to inhibit BIPN by antagonizing the PKC and ERK, respectively (Tsubaki et al., 2018a