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A common concern in drug synergy is the focus on combinations of agents with limited to null monotherapy activity (84)

This inherited effect acts through increased multigenerational vitellogenin transcription suggesting elevated nutrient provisioning

Interestingly, Janus kinase/signal transducer and activator of transcription (JAK/STAT) is involved in intracellular signaling pathways and mechanisms such as proliferation, differentiation and so on by translocation at the route of cytoplasm to nucleus and affecting down-stream targets (Losuwannarak et al., 2019

We also observed increased aggregate formation following incubation of the GST fusion proteins with cell lysate, which appears to depend on both the cell type and experimental conditions