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Haxaire C, Turpin FR, Potier B, Kervern M, Sinet PM, Barbanel G, Mothet JP, Dutar P, Billard JM (2012) Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation

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Raw reads were uploaded to the Galaxy server 80 and its instance at the University of Manchester ( QCed and trimmed using Trimmomatic 81 , then aligned to the mouse genome GRCm39 guided by the vM27.annotations from GENCODE 82 using HISAT2 aligner 83

TMAO activates its intracellular potential receptors, protein kinase R-like endoplasmic reticulum kinase (PERK), which further activates NLRP3 and NF-B that mediate pro-inflammatory responses