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ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation

All assays were run as per manufacturers recommendation, an overnight supernatant incubation protocol was used for all assays except Angiogenesis Panel 1 and Vascular Injury Panel 2, which were run according to the same day protocol

Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)

293 Some TZDs have shown cardiovascular-protective benefits, as pioglitazone reduced the risk of ASCVD in some trials

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