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Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities

These results suggest that the morphogenesis of DCX-positive immature neurons is impaired in the context of diabetes, and that hippocampal neurogenesis was disrupted in db/db mice

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Free Radic Biol Med 79:138146

Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response