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Experimental models show that high levels of IL-6 (but also TNF- and IL-1) in the lungs are directly related to longer exposure to hyperoxia [293,331,333,352]

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Histological analysis also showed that more CD4+ cells or F4/80+ cells were observed in the livers of Con A-injected WT mice than in those of Con A-injected Gpx1 KO mice (Figure 4b)

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These findings promote the hypothesis of melatonin acting against SQSTM1/p62, the cargo receptor that incites autophagic degradation or clockophagy of BMAL1/ARNTL and, by extension, the resulting ferroptosis [374]