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Study on analysis of peripheral biomarkers for Alzheimer's disease diagnosis

At the same time, they reduce antioxidant activity by decreasing GSH content and CAT activity [90, 91], enhancing DNA destruction, and stimulating different signals, resulting in apoptosis and cell death [92, 93]

Mitochondrial dysfunction regulates multiple programmed pathways, including apoptosis, pyroptosis and ferroptosis, thereby promoting tubular cell loss, inflammation and kidney dysfunction