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2012;7:e30042

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Zhang Y., Li Z., Liu X., Chen X., Zhang S., Chen Y., Chen J., Chen J., Wu J., Chen G.-Q

Maintenance therapy typically requires monthly 1000 mcg doses

Since both accumulation and complete elimination of BACE1/A adversely affect recovery after SCI, biological regulation of A or BACE1 levels after SCI by modulation of components of the UPS such as Fbx2-Uch-L1 via peroxisome proliferator-activated receptor-gamma co-activator (PGC)-1alpha or gene expression (Gong et al., 2010, 2013b) may be a feasible strategy for the SCI treatment and AD (Figure 3)