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Additionally, phosphorylation of tau protein was suppressed, indicating that naringenin interferes with key pathogenic processes in AD, including both amyloidogenesis and tauopathy (Okuyama et al., 2018)

E2F1 binds to canonical E2F motifs in the promoters of MAP1LC3B, ULK1 , and DRAM1 , activating their transcription and promoting autophagosome formation

It is used to treat Vitamin B12 deficiency, nerve damage, diabetic neuropathy, pernicious anemia and brain fog

Understanding stability relationships among three curcumin polymorphs

Its avascular, hypoxic, and acidic environment limits the survival of drugs and cells, and existing animal models cannot fully simulate the chronic pathological process of human IDD (Mai et al., 2025)