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The relationship between B12 and mental health is well established in medical literature, though it is primarily characterised by the psychiatric consequences of deficiency rather than excess

The effect of Fenugreek seed dry extract supplement on glycemic indices, lipid profile, and prooxidant-antioxidant balance in patients with type 2 diabetes: A double-blind randomized clinical trial

In IBD therapy, these include thiopurines, methotrexate, ciclosporin and biologic or targeted cell therapies[41]

In addition, B complex can provide health benefits like: May improve brain function The B vitamins play a role in keeping your brain healthy

While there are no universally agreed-upon "optimal" ranges, practitioners and specialty lab testing companies may base these on the levels of micronutrients in the blood that are associated with the best health outcomes (not just the absence of disease) in clinical research studies