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In neurodegeneration, mitochondrial dysfunction, NOX activity and impaired mitophagy foster protein/lipid oxidation, ONOO -driven nitration and iron-sensitized lipid peroxidation (Ischiropoulos and Beckman 2003)

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In addition, gastrodin treatment did not affect OPC proliferation or apoptosis as revealed by 5-Bromo-2-deoxyuridine (BrdU) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining (Supplementary Fig