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This decline is also associated with a decreased ability of these cells to migrate to lymph nodes, a crucial step for T cell activation [252, 253]

In mice in which genetically engineered deletion of xCT leads to deficiency in the glutamate/cystine antiporter system x, the prominent reduction of extrasynaptic L-glu is associated with a robust resistance of dopaminergic neurons against 6-hydroxydopamine-induced neurodegeneration (Massie et al., 2011), possibly as a result of decreased excitotoxicity

Cayman Chemical offers inhibitors for each of the major nodes within the ferroptotic pathway ( Figure 7 )