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Carnitine has been shown to be an endogenous substance with anti-inflammatory properties [47], as it inhibits the activity of NF-B and other core transcription factors involved in the inflammatory response and effectively reduces the levels of proinflammatory cytokines (e.g., IL-1, IL-6, and TNF-) [48, 49]

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Injectable L-carnitine can support weight loss through several mechanisms related to its role in fatty acid metabolism and energy production

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The Koeth findings established a biologically plausible mechanism and a population association, but the human cardiovascular evidence on supplemental L-carnitine is mixed some carnitine trials report neutral or even favorable cardiovascular markers, particularly in cardiac and metabolic patient populations