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KRAS: KRAS belongs to the Rat Sarcoma Viral Oncogene family (RAS), with the ability to hydrolyze GTP into GDP

Reactive Oxygen Species Reactive species (RS) are a broad term and include ROS, nitrogen [reactive nitrogen species (RNS)], sulfur [reactive sulfur species (RSS)], and other species, several of which are free radicals, and each has the potential to cause oxidative stress as a result of their accumulation within the cell to a level that exceeds the capacity to remove them (Mittler, 2017)

ERK1/2 regulates gene expression and survival pathways critical for cancer, with its dysregulation linked to poor outcomes

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Following the three-day reserpine injections, the animals received daily injections of IV physiological saline in the tail at noon for two weeks, starting on the fifth day