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They also contribute to brain homeostasis [308], mediate protective neuroinflammation, and promote neuronal plasticity at the site of neuronal injury [129]

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In vitro NAC amide, the amide form of NAC with improved membrane permeability, possessed the capacity to replenish GSH in red cells from -thalassemic patients and reduce the amount of ROS ( in vivo in children diagnosed with -thalassemia major: parameters of oxidative stress declined and erythrocyte life span improved ( In an attempt to reduce excessive oxidative stress in sickle red cells another compound gained interest: L-glutamine

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