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curcumin The oncogenic pathways inhibited by curcumin include down-regulation of epidermal growth factor receptors (EGFR and erbB2), Insulin- like growth factor type- 1 receptor (IFG-1R), sonic hedgehog (SHH)/GLIs) and Wnt/b-catenin and PARP, IKK, EGFR, JNK, MAPK and 5-LOX

PMP transfers the amino group to -KG to produce glutamate, restoring BCAT-PLP conformation (Figure 4) ( FIGURE 4 There are two isoenzymes of BCAT, cytosolic and mitochondrial forms

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